头孢呋辛钠相关物质(EP-H)的制备方法

以(Z)-2-甲氧亚氨基-2-(呋喃-2-基)乙酸铵为起始原料,经酰化反应、缩合反应内酯化应合成得到头孢呋辛钠1个有关物质(EP-H),并对其进行了HPLC、LC-MS、NMR及红外确证,为头孢呋辛钠杂质获取制备提供参考.     

8-(3-氯苯基)-3-甲硫基-1-苯基-吡唑并[3,4-d][1,2,4]三唑并[1,5-a]嘧啶-4-酮衍生物的合成与表征

以吡唑膦亚胺、3-氯苯基异氰酸酯和取代苯氧乙(丙)酰肼为原料,通过串联氮杂Wittig关环反应合成了6个未见文献报道的化合物8-(3-氯苯基)-3-甲硫基-1-苯基-吡唑并[3,4-d][1,2,4]三唑并[1,5-a]嘧啶-4-酮衍生物((1)a～(1)f),通过核磁共振氢碳谱和HRMS等确证进行了表征.     

8-(3-氯苯基)-3-甲硫基-1-苯基-吡唑并[3,4-d][1,2,4]三唑并[1,5-a]嘧啶-4-酮衍生物的合成与表征

以吡唑膦亚胺、3-氯苯基异氰酸酯和取代苯氧乙(丙)酰肼为原料,通过串联氮杂Wittig关环反应合成了6个未见文献报道的化合物8-(3-氯苯基)-3-甲硫基-1-苯基-吡唑并[3,4-d][1,2,4]三唑并[1,5-a]嘧啶-4-酮衍生物((1)a～(1)f),通过核磁共振氢碳谱和HRMS等确证进行了表征.     

基于提高弱电网新能源并网水平的逆变器功率-电压控制策略

传统功率-电流控制的并网逆变器存在谐波振荡等交互稳定性问题,限制了新能源的并网水平,尤其在弱交流电网中更为突出.为克服上述缺点,提出了一种新型功率-电压控制策略.首先在旋转dq坐标系下建立了逆变器输出阻抗的动态模型,包括主电路参数,锁相环(PLL)动态参数和调节器参数;然后基于波特图分析传统功率-电流控制策略下和本文所提功率-电压控制策略下逆变器输出阻抗的频率特性,证明了本文所提功率-电压控制策略稳定性,可以减小PLL带宽和输出功率的影响,从而提高弱电网中逆变器的额定功率注入功率,最后仿真和实验结果验证了所提出控制策略的有效性.     

考虑多元可控负荷协调的配网鲁棒优化经济调度模型

为有效应对大规模分布式可再生能源和可控负荷接入配网后在经济优化调度方面所带来的挑战,本文建立考虑多元可控负荷协调的配网鲁棒优化经济调度模型.首先考虑电池储能系统、电动汽车及可参与需求侧管理的电负荷的能量转移特性,建立多元可控负荷可调模型;进而考虑配网中多元可控负荷的调峰能力及动态约束以运行成本最低建立配网鲁棒经济优化调度模型;最后,以蒙东某配网实际数据为例,在改进IEEE 14节点配电系统上进行调度仿真分析,验证本文所提出模型可充分利用多元可控负荷的调节能力,有效提升配网运行经济性.     

席夫碱荧光探针对水系Zn2+的实时荧光标记与定量分析

为了实现水系Zn2+的实时检测与定量分析,设计以水杨醛苯甲酰腙作为Zn2+识别基团,引入具有特征性吸收的C=N键作为荧光发色团,合成得到一类新型席夫碱Zn2+荧光探针.通过IR、1H NMR、MS表征探针结构,采用FS分析探针光学性质、探针-Zn2+特异性识别和水系探针-Zn2+荧光标记性能.结果显示,该荧光探针能够特异性识别Zn2+,具有快速响应、光学信号稳定等优势,可用于水系Zn2+的定性检测和定量分析.在体外ECV304细胞荧光共聚焦显微成像实验中,细胞形态完整且荧光成像效果良好,说明探针对Zn2+的荧光标记产物具有较好的透膜性与低毒性,具有进一步应用于生命体中Zn2+标记示踪的前景.     

Multiple Na,K-ATPase Subunits Colocalize in the Brush Border of Mouse Choroid Plexus Epithelial Cells

(1) Background: The unusual accumulation of Na,K-ATPase complexes in the brush border membrane of choroid plexus epithelial cells have intrigued researchers for decades. However, the full range of the expressed Na,K-ATPase subunits and their relation to the microvillus cytoskeleton remains unknown. (2) Methods: RT-PCR analysis, co-immunoprecipitation, native PAGE, mass spectrometry, and differential centrifugation were combined with high-resolution immunofluorescence histochemistry, proximity ligase assays, and stimulated emission depletion (STED) microscopy on mouse choroid plexus cells or tissues in order to resolve these issues. (3) Results: The choroid plexus epithelium expresses Na,K-ATPase subunits α1, α2, β1, β2, β3, and phospholemman. The α1, α2, β1, and β2, subunits are all localized to the brush border membrane, where they appear to form a complex. The ATPase complexes may stabilize in the brush border membrane via anchoring to microvillar actin indirectly through ankyrin-3 or directly via other co-precipitated proteins. Aquaporin 1 (AQP1) may form part of the proposed multi-protein complexes in contrast to another membrane protein, the Na-K-2Cl cotransporter 1 (NKCC1). NKCC1 expression seems necessary for full brush border membrane accumulation of the Na,K-ATPase in the choroid plexus. (4) Conclusion: A multitude of Na,K-ATPase subunits form molecular complexes in the choroid plexus brush border, which may bind to the cytoskeleton by various alternative actin binding proteins.     

光储一体化系统三级互联隔离型电力电子变压器研究

该文在分析了模块化多电平变流器、电力电子变压器优劣势的基础上,设计了适用于光储一体化系统的三级互联隔离型电力电子变压器的结构和控制策略。结合光储一体化系统的实际应用情况,将电力电子变压器的整体结构设计成输入级多模块级联、隔离级CLLLC谐振变换器和输出级三电平逆变器的三级互联结构,并在10 kV配电网的整体设计方案下单独对每一级进行了结构及其控制策略的分析,最后在Simulink中进行了仿真,仿真结果表明：该结构中各级均可稳定、可靠运行,且系统整体暂稳态性能良好。     

计及风/光/荷不确定性的综合能源站随机规划研究

传统变电站灵活性较差,可再生能源消纳能力有限,导致弃风弃光现象严重。在此背景下,提出了一种计及风/光/荷不确定性的综合能源站随机规划方法。首先,将综合能源制氢站的规划总周期划分为若干个子周期;然后,在各个子周期内采用蒙特卡罗法对风、光年利用小时数模型和电、氢负荷分布模型进行模拟,以设备全寿命周期成本最小为目标,建立包括电解水装置和储能设备在内的随机规划模型,并通过非线性规划求解器求解。最后,通过算例分析,可验证文章所提周期性随机规划方法在提升综合能源站经济效益、可再生能源利用率和供能可靠性等方面的有效性。     

Video multipath transmission mechanism with load balancing in the FiWi network

Aiming at the differentiated needs of users and the problem of video service interruption caused by the local overload of the converged network,a load-balanced video transmission mechanism is proposed.First,the split multipath routing protocol is improved to obtain the path selection model according to the front-end structural characteristics of the optical fiber wireless access network;second,we calculate the path differential delay and the video transmission delay on wireless side,and set their threshold as the quality of the experience constraint.Finally,while considering the quality of user experience,a particle swarm optimization algorithm with a multi-stage penalty function is used for video distribution.Simulation results show that the proposed mechanism is better than the throughput-aware load-sensing algorithms,enhances delay-control load distribution algorithms and delay-energy-quality aware multipath algorithms,and that it can effectively balance the network load and alleviate network congestion while avoiding user loss.